Perceived Discrimination and Trajectories of C-Reactive Protein: The Jackson Heart Study.

ABSTRACT:

Introduction

Perceiving discriminatory treatment may contribute to systemic inflammation, a risk factor of cardiovascular pathophysiology. This study evaluated the association of self-reported discrimination with changes in high-sensitivity C-reactive protein and the mediating role of adiposity.

Methods

The sample included 5,145 African-Americans, aged 21-92 years, in the Jackson Heart Study. Everyday, lifetime, and burden from perceived discrimination comprised primary predictors in 3 sets of multivariable linear regression models of baseline (2000-2004) discrimination and natural logarithm of high-sensitivity C-reactive protein. Multivariable linear mixed models assessed mean changes in natural logarithm of high-sensitivity C-reactive protein over the study period (2000-20

SUBMITTER: Sims KD 

PROVIDER: S-EPMC6985923 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature