Tylosin exposure reduces the susceptibility of Salmonella Typhimurium to florfenicol and tetracycline.

ABSTRACT:

Background

Antibiotics exposure has been implicated in the emergence of bacterial strains that are resistant to structurally related or unrelated antibiotics. Tylosin is a macrolide antibiotic that has been administered to treat respiratory pathogenic bacteria in swine. Thus, this study was undertaken to evaluate the impact of exposure to a constant (3 μg/mL) and decreasing concentrations of tylosin on the susceptibility of Salmonella enterica serovar Typhimurium to various antibiotics.

Results

S. Typhimurium strains exposed to tylosin for 12 and 24 h in the in vitro dynamic model demonstrated at least an eight-fold increase in the minimum inhibitory concentrations (MICs) of florfenicol and tetracycline. Exposure to tylosin extended the lag-time of the growth curve and enhan

SUBMITTER: Mechesso AF 

PROVIDER: S-EPMC6986020 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature