Umbilical cord-matrix stem cells induce the functional restoration of vascular endothelial cells and enhance skin wound healing in diabetic mice via the polarized macrophages.

ABSTRACT:

Background

Chronic nonhealing wounds represent one of the most common complications of diabetes and require advanced treatment strategies. Increasing evidence supports the important role of mesenchymal stem cells in diabetic wound healing; however, the underlying mechanism remains unclear. Here, we explored the effects of umbilical cord-matrix stem cells (UCMSCs) on diabetic wound healing and the underlying mechanism.

Methods

UCMSCs or conditioned medium (UCMSC-CM) were injected into the cutaneous wounds of streptozotocin-induced diabetic mice. The effects of this treatment on macrophages and diabetic vascular endothelial cells were investigated in vivo and in vitro.

Results

Our results reveal that UCMSCs or UCMSC-CM accelerated wound healing by enhancing angiogenesis

SUBMITTER: Zhang S 

PROVIDER: S-EPMC6986138 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature