MiR-183-96-182 Cluster Is Involved in Invariant NKT Cell Development, Maturation, and Effector Function.

ABSTRACT: The development, differentiation and function of invariant NKT (iNKT) cells require a well-defined set of transcription factors, but how these factors are integrated to each other and the detailed signaling networks remain poorly understood. Using a Dicer-deletion mouse model, our previous studies have demonstrated the critical involvement of microRNAs (miRNAs) in iNKT cell development and function, but the role played by individual miRNAs in iNKT cell development and function is still not clear. In this study, we show the dynamic changes of miRNA 183 cluster (miR-183C) expression during iNKT cell development. Mice with miR-183C deletion showed a defective iNKT cell development, sublineage differentiation, and cytokine secretion function. miRNA target identification assays indicate the inv

SUBMITTER: Wang J 

PROVIDER: S-EPMC6986331 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature