Glomerular hyperfiltration is associated with dementia: A nationwide population-based study.

ABSTRACT: BACKGROUND:Glomerular hyperfiltration may be a clinical phenotype of endothelial dysfunction. Endothelial dysfunction may cause vascular dementia through the deterioration of cerebral blood flow. We aimed to identify the risk of dementia in people with glomerular hyperfiltration. METHODS:Using the Korean National Health Information Database, we included subjects aged ≥45 years who underwent national health screening examinations between 2012 and 2015 and who had no previous history of end-stage renal disease or dementia (n = 2,244,582). The primary exposure was glomerular hyperfiltration. We divided the subjects into groups by sex and five-year age intervals and categorized each group into 8 intervals according to estimated glomerular filtration (eGFR). The subjects with an eGFR ≥95th perc

SUBMITTER: Kang MW 

PROVIDER: S-EPMC6986766 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature