Contrasting effects of acute and chronic stress on the transcriptome, epigenome, and immune response of Atlantic salmon.

ABSTRACT: Stress experienced during early life may have lasting effects on the immune system, with impacts on health and disease dependent on the nature and duration of the stressor. The epigenome is especially sensitive to environmental stimuli during early life and represents a potential mechanism through which stress may cause long-lasting health effects. However, the extent to which the epigenome responds differently to chronic vs acute stressors is unclear, especially for non-mammalian species. We examined the effects of acute stress (cold-shock during embryogenesis) and chronic stress (absence of tank enrichment during larval-stage) on global gene expression (using RNA-seq) and DNA methylation (using RRBS) in the gills of Atlantic salmon (Salmo salar) four months after hatching. Chronic stress

SUBMITTER: Uren Webster TM 

PROVIDER: S-EPMC6986783 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature