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Exposure to Ebola Virus and Risk for Infection with Malaria Parasites, Rural Gabon.


ABSTRACT: An association between malaria and risk for death among patients with Ebola virus disease has suggested within-host interactions between Plasmodium falciparum parasites and Ebola virus. To determine whether such an interaction might also influence the probability of acquiring either infection, we used a large snapshot surveillance study from rural Gabon to test if past exposure to Ebola virus is associated with current infection with Plasmodium spp. during nonepidemic conditions. We found a strong positive association, on population and individual levels, between seropositivity for antibodies against Ebola virus and the presence of Plasmodium parasites in the blood. According to a multiple regression model accounting for other key variables, antibodies against Ebola virus emerged as the strongest individual-level risk factor for acquiring malaria. Our results suggest that within-host interactions between malaria parasites and Ebola virus may underlie epidemiologic associations.

SUBMITTER: Abbate JL 

PROVIDER: S-EPMC6986822 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Exposure to Ebola Virus and Risk for Infection with Malaria Parasites, Rural Gabon.

Abbate Jessica L JL   Becquart Pierre P   Leroy Eric E   Ezenwa Vanessa O VO   Roche Benjamin B  

Emerging infectious diseases 20200217 2


An association between malaria and risk for death among patients with Ebola virus disease has suggested within-host interactions between Plasmodium falciparum parasites and Ebola virus. To determine whether such an interaction might also influence the probability of acquiring either infection, we used a large snapshot surveillance study from rural Gabon to test if past exposure to Ebola virus is associated with current infection with Plasmodium spp. during nonepidemic conditions. We found a stro  ...[more]

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