Somatostatin secretion by Na⁺-dependent Ca²⁺-induced Ca²⁺ release in pancreatic delta-cells.

ABSTRACT: Pancreatic islets are complex micro-organs consisting of at least three different cell types: glucagon-secreting α-, insulin-producing β- and somatostatin-releasing δ-cells¹. Somatostatin is a powerful paracrine inhibitor of insulin and glucagon secretion². In diabetes, increased somatostatinergic signalling leads to defective counter-regulatory glucagon secretion³. This increases the risk of severe hypoglycaemia, a dangerous complication of insulin therapy⁴. The regulation of somatostatin secretion involves both intrinsic and paracrine mechanisms⁵ but their relative contributions and whether they interact remains unclear. Here we show that dapagliflozin-sensitive glucose- and insulin-dependent sodium uptake stimulates somatostatin sec

SUBMITTER: Vergari E 

PROVIDER: S-EPMC6986923 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature