Tracing the origin of adult intestinal stem cells.

ABSTRACT: Adult intestinal stem cells are located at the bottom of crypts of Lieberkühn, where they express markers such as LGR5^1,2 and fuel the constant replenishment of the intestinal epithelium¹. Although fetal LGR5-expressing cells can give rise to adult intestinal stem cells^3,4, it remains unclear whether this population in the patterned epithelium represents unique intestinal stem-cell precursors. Here we show, using unbiased quantitative lineage-tracing approaches, biophysical modelling and intestinal transplantation, that all cells of the mouse intestinal epithelium-irrespective of their location and pattern of LGR5 expression in the fetal gut tube-contribute actively to the adult intestinal stem cell pool. Using 3D imaging, we find that during fetal developm

SUBMITTER: Guiu J 

PROVIDER: S-EPMC6986928 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature