Age-related decreases in relapses among adults with relapsing-onset multiple sclerosis.

ABSTRACT:

Background

Relapsing-onset multiple sclerosis (MS) typically starts in early- to mid-adulthood, yet the trajectory of disease activity over the subsequent lifetime remains poorly defined. Previous studies have not quantified the age-specific portion of decreases in annualized relapse rates (ARR).

Objective

The aim of this article is to determine, under a range of disease-related assumptions, the age-specific component of decreases in ARR over time among adults with relapsing-onset MS.

Methods

We used a simulation modeling approach to examine a range of assumptions about changes in ARR due to age versus disability status. Scenarios included variations in initial ARR and rate of worsening on the Expanded Disability Status Scale. Model parameters were developed through a

SUBMITTER: Schwehr NA 

PROVIDER: S-EPMC6986982 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature