Neuronal Autophagy in Synaptic Functions and Psychiatric Disorders.

ABSTRACT: Homeostatic maintenance of physiological functions is fundamental to organismal well-being. Disruption or imbalance in homeostasis results in functional disturbances at molecular, cellular, and tissue levels, leading to manifestation as physical and mental illnesses. Homeostatic imbalance is caused by a range of pathophysiological mechanisms, including disrupted reduction-oxidation reactions, inflammatory responses, metabolic disturbances, or failure in quality control of cellular proteins and organelles. However, the roles for the protein/organelle quality control in the regulation of behaviors, in particular of cognitive processes, had not been well documented, until recent reports finally supported this concept. The frontline studies in neuroscience have revealed that synaptic component

SUBMITTER: Tomoda T 

PROVIDER: S-EPMC6986983 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature