Platelets induce increased estrogen production through NF-κB and TGF-β1 signaling pathways in endometriotic stromal cells.

ABSTRACT: Endometriosis is estrogen-dependent disorder. Two theories provide the explanations for the increased estrogen production. One is the feed-forward loop model linking inflammation and estrogen production. The more recent model evokes the tissue hypoxia resulting from endometrial debris detached and then regurgitated to the peritoneal cavity. Both models tacitly assume that everything occurs within the endometriotic stromal cells, seemingly without the need for exogenous factors. This study was undertaken to investigate as whether platelets may be responsible for local estrogen overproduction. We employed in vitro experimentation that evaluated the 17β-estradiol (E₂) levels in endometriotic stromal cells treated with activated platelets, and the genes and protein expression levels

SUBMITTER: Qi Q 

PROVIDER: S-EPMC6987096 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature