Ontology highlight
ABSTRACT:
SUBMITTER: Maimaiti M
PROVIDER: S-EPMC6987139 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Maimaiti Maihulan M Sakamoto Shinichi S Yamada Yasutaka Y Sugiura Masahiro M Rii Junryo J Takeuchi Nobuyoshi N Imamura Yusuke Y Furihata Tomomi T Ando Keisuke K Higuchi Kosuke K Xu Minhui M Sazuka Tomokazu T Nakamura Kazuyoshi K Kaneda Atsushi A Kanai Yoshikatsu Y Kyprianou Natasha N Ikehara Yuzuru Y Anzai Naohiko N Ichikawa Tomohiko T
Scientific reports 20200128 1
L-type amino acid transporter 1 (LAT1) plays a role in transporting essential amino acids including leucine, which regulates the mTOR signaling pathway. Here, we studied the expression profile and functional role of LAT1 in bladder cancer. Furthermore, the pharmacological activity of JPH203, a specific inhibitor of LAT1, was studied in bladder cancer. LAT1 expression in bladder cancer cells was higher than that in normal cells. SiLAT1 and JPH203 suppressed cell proliferative and migratory and in ...[more]