Fusion transcripts in normal human cortex increase with age and show distinct genomic features for single cells and tissues.

ABSTRACT: Fusion transcripts can contribute to diversity of molecular networks in the human cortex. In this study, we explored the occurrence of fusion transcripts in normal human cortex along with single neurons and astrocytes. We identified 1305 non-redundant fusion events from 388 transcriptomes representing 59 human cortices and 329 single cells. Our results indicate while the majority of fusion transcripts in human cortex are intra-chromosomal (85%), events found in single neurons and astrocytes were primarily inter-chromosomal (80%). The number of fusions in single neurons was significantly higher than that in single astrocytes (p < 0.05), indicating fusion as a possible contributor towards transcriptome diversity in neuronal cells. The identified fusions were largely private and 4 specific re

SUBMITTER: Mehani B 

PROVIDER: S-EPMC6987184 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature