Visceral fat metabolic activity evaluated by preoperative ¹⁸F-FDG PET/CT significantly affects axillary lymph node metastasis in postmenopausal luminal breast cancer.

ABSTRACT: Obesity is known to increase breast cancer risk and aggressiveness in postmenopausal luminal breast cancer and obesity-driven dysfunctional metabolic activity in visceral adipose tissue (VAT) is considered as one of the principal underlying mechanism. We aimed to investigate the relationship between VAT metabolic activity evaluated by preoperative ¹⁸F-FDG PET/CT and axillary lymph node (ALN) metastasis in postmenopausal luminal breast cancer patients. In total, 173 patients were enrolled in study. They all underwent preoperative ¹⁸F-FDG PET/CT and surgery. VAT metabolic activity was defined as the maximum standardized uptake value (SUVmax) of VAT divided by the SUVmax of subcutaneous adipose tissue (V/S ratio). In luminal breast cancer, the patients with ALN metastasi

SUBMITTER: Pahk K 

PROVIDER: S-EPMC6987196 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature