Animal Functional Magnetic Resonance Imaging: Trends and Path Toward Standardization.

ABSTRACT: Animal whole-brain functional magnetic resonance imaging (fMRI) provides a non-invasive window into brain activity. A collection of associated methods aims to replicate observations made in humans and to identify the mechanisms underlying the distributed neuronal activity in the healthy and disordered brain. Animal fMRI studies have developed rapidly over the past years, fueled by the development of resting-state fMRI connectivity and genetically encoded neuromodulatory tools. Yet, comparisons between sites remain hampered by lack of standardization. Recently, we highlighted that mouse resting-state functional connectivity converges across centers, although large discrepancies in sensitivity and specificity remained. Here, we explore past and present trends within the animal fMRI community

SUBMITTER: Mandino F 

PROVIDER: S-EPMC6987455 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature