Extent and characteristics of immune infiltration in clear cell renal cell carcinoma and the prognostic value.

ABSTRACT:

Background

Immune infiltration has an important impact on the development of clear cell renal cell carcinoma (ccRCC). This article aims to investigate the association between immune infiltration and the clinical features as well as prognosis of clear cell renal cell carcinoma.

Methods

Analyze the immune infiltration in ccRCC by applying ESTIMATE and CIBERSORT methods on basic of dataset in TCGA and GEO. And identify the kind of immune cell and genes that may play the central role.

Results

High Immune score and high property of T-regs are both significantly associated with the poor OS, high stage and more chances of metastases in ccRCC. CXCL-1, SAA1, PMCH, CCL-5 are all significantly negatively correlated to OS and positively correlated to stage and chance of metastase

SUBMITTER: Wang Y 

PROVIDER: S-EPMC6987603 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature