Connectome hubs at resting state in children and adolescents: Reproducibility and psychopathological correlation.

ABSTRACT: Functional brain hubs are key integrative regions in brain networks. Recently, brain hubs identified through resting-state fMRI have emerged as interesting targets to increase understanding of the relationships between large-scale functional networks and psychopathology. However, few studies have directly addressed the replicability and consistency of the hub regions identified and their association with symptoms. Here, we used the eigenvector centrality (EVC) measure obtained from graph analysis of two large, independent population-based samples of children and adolescents (7-15 years old; total N=652; 341 subjects for site 1 and 311 for site 2) to evaluate the replicability of hub identification. Subsequently, we tested the association between replicable hub regions and psychiatric sympt

SUBMITTER: Sato JR 

PROVIDER: S-EPMC6987719 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature