Progression of Arterial Stiffness is Associated With Midlife Diastolic Blood Pressure and Transition to Late-Life Hypertensive Phenotypes.

ABSTRACT: Background Hypertension-associated cardiovascular events are particularly associated with elevated systolic blood pressure (SBP) in late life, yet long-term interactions between SBP, diastolic BP (DBP) and arterial stiffness in development of late-life hypertensive phenotypes remain unclear. Methods and Results In the UK Biobank, we determined associations between arterial stiffness index (ASI), SBP, DBP, and their progression, and transition from normotension (<140/90 mm Hg) to hypertension or elevated ASI (>10 m/s). Associations were determined by general linear and logistic regression, adjusted for cardiovascular risk factors and variability of measurements across follow-ups. Mean values of baseline SBP, DBP, and ASI were determined stratified by deciles of age, blood pressure, and ASI,

SUBMITTER: Webb AJS 

PROVIDER: S-EPMC6988142 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature