The association of CASC16 variants with breast Cancer risk in a northwest Chinese female population.

ABSTRACT:

Purpose

Genetic variants play a critical role in the development of breast cancer. This investigation aimed to explore the association between CASC16 polymorphisms and breast cancer susceptibility.

Methods

We conducted a case-control study of 681 patients and 680 healthy individuals to investigate the correlation of five SNPs with breast cancer in a Northwest Chinese female population. Odds ratios (OR) and 95% confidence intervals (CIs) were used to assess the association.

Results

Our study found that rs4784227 and rs12922061 were significantly related to an increased susceptibility to breast cancer (OR 1.22, p = 0.022; OR 1.21, p = 0.026). While rs3803662 was a protective role in breast cancer risk (OR 0.69, p = 0.042). Stratified analyses indicated that rs4784227 an

SUBMITTER: Zuo X 

PROVIDER: S-EPMC6988193 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature