Diverse biological processes coordinate the transcriptional response to nutritional changes in a Drosophila melanogaster multiparent population.

ABSTRACT: BACKGROUND:Environmental variation in the amount of resources available to populations challenge individuals to optimize the allocation of those resources to key fitness functions. This coordination of resource allocation relative to resource availability is commonly attributed to key nutrient sensing gene pathways in laboratory model organisms, chiefly the insulin/TOR signaling pathway. However, the genetic basis of diet-induced variation in gene expression is less clear. RESULTS:To describe the natural genetic variation underlying nutrient-dependent differences, we used an outbred panel derived from a multiparental population, the Drosophila Synthetic Population Resource. We analyzed RNA sequence data from multiple female tissue samples dissected from flies reared in three nutritional co

SUBMITTER: Ng'oma E 

PROVIDER: S-EPMC6988245 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature