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Functional and population genetic features of copy number variations in two dairy cattle populations.

ABSTRACT: BACKGROUND:Copy Number Variations (CNVs) are gain or loss of DNA segments that are known to play a role in shaping a wide range of phenotypes. In this study, we used two dairy cattle populations, Holstein Friesian and Jersey, to discover CNVs using the Illumina BovineHD Genotyping BeadChip aligned to the ARS-UCD1.2 assembly. The discovered CNVs were investigated for their functional impact and their population genetics features. RESULTS:We discovered 14,272 autosomal CNVs, which were aggregated into 1755 CNV regions (CNVR) from 451 animals. These CNVRs together cover 2.8% of the bovine autosomes. The assessment of the functional impact of CNVRs showed that rare CNVRs (MAF?

SUBMITTER: Lee YL 

PROVIDER: S-EPMC6988284 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Functional and population genetic features of copy number variations in two dairy cattle populations.

Lee Young-Lim YL   Bosse Mirte M   Mullaart Erik E   Groenen Martien A M MAM   Veerkamp Roel F RF   Bouwman Aniek C AC  

BMC genomics 20200128 1

<h4>Background</h4>Copy Number Variations (CNVs) are gain or loss of DNA segments that are known to play a role in shaping a wide range of phenotypes. In this study, we used two dairy cattle populations, Holstein Friesian and Jersey, to discover CNVs using the Illumina BovineHD Genotyping BeadChip aligned to the ARS-UCD1.2 assembly. The discovered CNVs were investigated for their functional impact and their population genetics features.<h4>Results</h4>We discovered 14,272 autosomal CNVs, which w  ...[more]

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