Key genes with prognostic values in suppression of osteosarcoma metastasis using comprehensive analysis.

ABSTRACT: BACKGROUND:Osteosarcoma is a primary malignant tumor originating from mesenchymal tissue, with a poor distant metastasis prognosis. The molecular mechanisms of osteosarcoma metastasis are extremely complicated. METHODS:A public data series (GSE21257) was used to identify differentially expressed genes (DEGs) in osteosarcoma patients that did, or did not, develop metastases. Functional enrichment analysis, a protein-protein interaction network, and survival analysis of DEGs were performed. DEGs with a prognostic value were considered as candidate genes and their functional predictions, different expression in normal and malignant tissues, and immune infiltration were analyzed. RESULTS:The DEGs were mainly enriched in the immune response. Three candidate genes (ALOX5AP, CD74, and FCGR2A) wer

SUBMITTER: Li M 

PROVIDER: S-EPMC6988291 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature