Expression of SMARCD1 interacts with age in association with asthma control on inhaled corticosteroid therapy.

ABSTRACT:

Background

Global gene expression levels are known to be highly dependent upon gross demographic features including age, yet identification of age-related genomic indicators has yet to be comprehensively undertaken in a disease and treatment-specific context.

Methods

We used gene expression data from CD4+ lymphocytes in the Asthma BioRepository for Integrative Genomic Exploration (Asthma BRIDGE), an open-access collection of subjects participating in genetic studies of asthma with available gene expression data. Replication population participants were Puerto Rico islanders recruited as part of the ongoing Genes environments & Admixture in Latino Americans (GALA II), who provided nasal brushings for transcript sequencing. The main outcome measure was chronic asthma control a

SUBMITTER: McGeachie MJ 

PROVIDER: S-EPMC6988322 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature