Different macrophage polarization between drug-susceptible and multidrug-resistant pulmonary tuberculosis.

ABSTRACT:

Background

Macrophages play a key role in the infection process, and alternatively activated macrophages (M2 polarization) play important roles in persistent infection via the immune escape of pathogens. This suggests that immune escape of pathogens from host immunity is an important factor to consider in treatment failure and multidrug-resistant tuberculosis (MDR-TB)/extensively drug-resistant tuberculosis (XDR-TB). In this study, we investigated the association between macrophage polarization and MDR-TB/XDR-TB and the association between macrophage polarization and the anti-TB drugs used.

Methods

iNOS and arginase-1, a surface marker of polarized macrophages, were quantified by immunohistochemical staining and imaging analysis of lung tissues of patients who underwent surg

SUBMITTER: Cho HJ 

PROVIDER: S-EPMC6988333 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature