Molecular methods for tracking residual Plasmodium falciparum transmission in a close-to-elimination setting in Zanzibar.

ABSTRACT:

Background

Molecular detection of low-density Plasmodium falciparum infections is essential for surveillance studies conducted to inform malaria control strategies in close-to-elimination settings. Molecular monitoring of residual malaria infections usually requires a large study size, therefore sampling and diagnostic processes need to be economical and optimized for high-throughput. A method comparison was undertaken to identify the most efficient diagnostic procedure for processing large collections of community samples with optimal test sensitivity, simplicity, and minimal costs.

Methods

In a reactive case detection study conducted on Zanzibar, parasitaemia of 4590 individuals of all ages was investigated by a highly sensitive quantitative (q) PCR that targets multiple v

SUBMITTER: Grossenbacher B 

PROVIDER: S-EPMC6988349 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature