TRPC1 mediates slow excitatory synaptic transmission in hippocampal oriens/alveus interneurons.

ABSTRACT: Hippocampal GABAergic interneurons play key roles in regulating principal cell activity and plasticity. Interneurons located in stratum oriens/alveus (O/A INs) receive excitatory inputs from CA1 pyramidal cells and express a Hebbian form of long-term potentiation (LTP) at their excitatory input synapses. This LTP requires the activation of metabotropic glutamate receptors 1a (mGluR1a) and Ca²⁺ entry via transient receptor potential (TRP) channels. However, the type of TRP channels involved in synaptic transmission at these synapses remains largely unknown. Using patch-clamp recordings, we show that slow excitatory postsynaptic currents (EPSCs) evoked in O/A INs are dependent on TRP channels but may be independent of phospholipase C. Using reverse transcription polymerase chain r

SUBMITTER: Kougioumoutzakis A 

PROVIDER: S-EPMC6988362 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature