Immune network dysregulation associated with child neurodevelopmental delay: modulatory role of prenatal alcohol exposure.

ABSTRACT:

Background

Evidence suggests that cytokine imbalances may be at the root of deficits that occur in numerous neurodevelopmental disorders, including schizophrenia and autism spectrum disorder. Notably, while clinical studies have demonstrated maternal cytokine imbalances with alcohol consumption during pregnancy-and data from animal models have identified immune disturbances in alcohol-exposed offspring-to date, immune alterations in alcohol-exposed children have not been explored. Thus, here we hypothesized that perturbations in the immune environment as a result of prenatal alcohol exposure will program the developing immune system, and result in immune dysfunction into childhood. Due to the important role of cytokines in brain development/function, we further hypothesized that ch

SUBMITTER: Bodnar TS 

PROVIDER: S-EPMC6988366 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature