American Society of Hematology 2020 guidelines for sickle cell disease: transfusion support.

ABSTRACT:

Background

Red cell transfusions remain a mainstay of therapy for patients with sickle cell disease (SCD), but pose significant clinical challenges. Guidance for specific indications and administration of transfusion, as well as screening, prevention, and management of alloimmunization, delayed hemolytic transfusion reactions (DHTRs), and iron overload may improve outcomes.

Objective

Our objective was to develop evidence-based guidelines to support patients, clinicians, and other healthcare professionals in their decisions about transfusion support for SCD and the management of transfusion-related complications.

Methods

The American Society of Hematology formed a multidisciplinary panel that was balanced to minimize bias from conflicts of interest and that included a

SUBMITTER: Chou ST 

PROVIDER: S-EPMC6988392 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature