Direct, indirect and pleiotropic effects of candidate genes on internalizing disorder psychopathology.

ABSTRACT:

Background

Twin studies of internalizing disorders suggest that their high co-morbidity is partially explained by shared genetic risk. Few studies have investigated pleiotropic effects of well-validated candidate genes across phenotypes.

Method

Subjects were 928 Caucasian patients who presented to an out-patient clinic specializing in the assessment and treatment of anxiety and mood disorders. We constructed latent dimensional phenotypes across the internalizing spectrum (neuroticism, extraversion, depression, generalized anxiety, panic/agoraphobia, social phobia, post-traumatic stress, and obsessions-compulsions) by combining diagnostic criteria with other clinical indicators. We selected multiple variants in four evidence-based candidate genes (SLC6A4, COMT, GAD1, RGS2) wi

SUBMITTER: Hettema JM 

PROVIDER: S-EPMC6988508 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature