Multiple doses of adipose tissue-derived mesenchymal stromal cells induce immunosuppression in experimental asthma.

ABSTRACT: In experimental house dust mite (HDM)-induced allergic asthma, therapeutic administration of a single dose of adipose tissue-derived mesenchymal stromal cells (MSCs) ameliorates lung inflammation but is unable to reverse remodeling. We hypothesized that multiple doses of MSCs might exert better therapeutic effects by reducing lung inflammation and remodeling but might also result in immunosuppressive effects in experimental asthma. HDM was administered intranasally in C57BL/6 mice. After the last HDM challenge, mice received two or three doses of MSCs (10⁵ cells per day) or saline intravenously. An additional cohort of mice received dexamethasone as a positive control for immunosuppression. Two and three doses of MSCs reduced lung inflammation, levels of interleukin (IL)-4, IL-1

SUBMITTER: Castro LL 

PROVIDER: S-EPMC6988761 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature