Autologous cord blood cell infusion in preterm neonates safely reduces respiratory support duration and potentially preterm complications.

ABSTRACT: Preterm birth and its complications are the leading cause of neonatal death. The main underlying pathological mechanisms for preterm complications are disruption of the normal maturation processes within the target tissues, interrupted by premature birth. Cord blood, as a new and convenient source of stem cells, may provide new, promising options for preventing preterm complications. This prospective, nonrandomized placebo controlled study aimed at investigating the effect of autologous cord blood mononuclear cells (ACBMNC) for preventing preterm associated complications. Preterm infants less than 35 weeks gestational age were assigned to receive ACBMNC (5 × 10⁷ cells/kg) intravenous or normal saline within 8 hours after birth. Preterm complication rates were compared between tw

SUBMITTER: Ren Z 

PROVIDER: S-EPMC6988763 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature