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Stereoselective Four-Component Synthesis of Functionalized 2,3-Dihydro-4-Nitropyrroles.

ABSTRACT: We report a metal-free and stereoselective four-component reaction between ?-ketoamides, amines, aromatic aldehydes and ?-nitroalkenes or ?-pivaloxy-nitroalkanes to obtain 2,3-dihydro-4-nitropyrroles functionalized in every position. The heterocycles accessible using this reaction may have utility in the synthesis of pharmacologically active compounds.

SUBMITTER: Wang D

PROVIDER: S-EPMC6988783 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Stereoselective Four-Component Synthesis of Functionalized 2,3-Dihydro-4-Nitropyrroles.

Wang Dong D Ma Xinyue X Dong Linru L Feng Hairong H Yu Peng P Désaubry Laurent L

Frontiers in chemistry 20191126

We report a metal-free and stereoselective four-component reaction between α-ketoamides, amines, aromatic aldehydes and β-nitroalkenes or β-pivaloxy-nitroalkanes to obtain 2,3-dihydro-4-nitropyrroles functionalized in every position. The heterocycles accessible using this reaction may have utility in the synthesis of pharmacologically active compounds. ...[more]

PMID: 32039135

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