Lrp5 and Lrp6 are required for maintaining self-renewal and differentiation of hematopoietic stem cells.

ABSTRACT: Hematopoietic stem cells (HSCs) have the capacity for self-renewal to maintain the HSCs' pool and the ability for multilineage differentiation, which are responsible for sustained production of multiple blood lineages. The regulation of HSC development is controlled precisely by complex signal networks and hematopoietic microenvironment, which has been termed the HSCs' niche. The Wnt signaling pathway is one of a variety of signaling pathways that have been involved in HSC self-renewal and maintenance. Previous studies are indeterminant on the regulation of adult HSCs upon canonical Wnt signaling pathways because of the different experimental systems and models used. In this study, we generated the conditional knockout Wnt coreceptor low-density lipoprotein receptor-related protein 5 (Lrp5

SUBMITTER: Liu J 

PROVIDER: S-EPMC6988868 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature