Total and specific immunoglobulin E in induced sputum in allergic and non-allergic asthma.

ABSTRACT:

Background

Most patients with nonallergic asthma have normal serum immunoglobulin E (IgE) levels. Recent reports suggest that total and aeroallergen-specific IgE levels in induced sputum may be higher in nonallergic asthmatics than in healthy controls. Our objective is to compare total and dust-mite specific (Der p 1) IgE levels in induced sputum in allergic and nonallergic asthmatics and healthy controls.

Methods

Total and Der p 1-specific IgE were measured in induced sputum (ImmunoCAP immunoassay) from 56 age- and sex-matched asthmatics (21 allergic, 35 nonallergic) and 9 healthy controls. Allergic asthma was defined as asthma with a positive prick test and/or clinically-significant Der p 1-specific serum IgE levels.

Results

Patients with allergic asthma presented s

SUBMITTER: Crespo-Lessmann A 

PROVIDER: S-EPMC6988954 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature