Transcriptome analysis of early pregnancy vitamin D status and spontaneous preterm birth.

ABSTRACT:

Background

We conducted a literature review on the studies that investigated the relationship of preterm birth, including spontaneous preterm birth (sPTB), with vitamin D status. Overall, these studies demonstrated that the incidence of sPTB was associated with maternal vitamin D insufficiency in early pregnancy. However, the potential mechanisms and biological pathways are unknown.

Objectives

To investigate early pregnancy gene expression signatures associated with both vitamin D insufficiency and sPTB. We further constructed a network of these gene signatures and identified the common biological pathways involved.

Study design

We conducted peripheral blood transcriptome profiling at 10-18 weeks of gestation in a nested case-control cohort of 24 pregnant women who pa

SUBMITTER: Yadama AP 

PROVIDER: S-EPMC6988958 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature