Causal relationships between lipid and glycemic levels in an Indian population: A bidirectional Mendelian randomization approach.

ABSTRACT:

Background

Dyslipidemia and abnormal glycemic traits are leading causes of morbidity and mortality. Although the association between the two traits is well established, there still exists a gap in the evidence for the direction of causality.

Objective

This study aimed to examine the direction of the causal relationship between lipids and glycemic traits in an Indian population using bidirectional Mendelian randomization (BMR).

Methods

The BMR analysis was conducted on 4900 individuals (2450 sib-pairs) from the Indian Migration Study. Instrument variables were generated for each lipid and glycemic trait (fasting insulin, fasting glucose, HOMA-IR, HOMA-β, LDL-cholesterol, HDL-cholesterol, total cholesterol and triglycerides) to examine the causal relationship by applyin

SUBMITTER: Agarwal T 

PROVIDER: S-EPMC6988960 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature