The age-specific burden and household and school-based predictors of child and adolescent tuberculosis infection in rural Uganda.

ABSTRACT:

Background

The age-specific epidemiology of child and adolescent tuberculosis (TB) is poorly understood, especially in rural areas of East Africa. We sought to characterize the age-specific prevalence and predictors of TB infection among children and adolescents living in rural Uganda, and to explore the contribution of household TB exposure on TB infection.

Methods

From 2015-2016 we placed and read 3,121 tuberculin skin tests (TST) in children (5-11 years old) and adolescents (12-19 years old) participating in a nested household survey in 9 rural Eastern Ugandan communities. TB infection was defined as a positive TST (induration ≥10mm or ≥5mm if living with HIV). Age-specific prevalence was estimated using inverse probability weighting to adjust for incomplete measurement.

SUBMITTER: Marquez C 

PROVIDER: S-EPMC6988961 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature