Longitudinal associations between diurnal cortisol variation and later-life cognitive impairment.

ABSTRACT:

Objective

To determine whether hypothalamus-pituitary-adrenal axis (HPAA) dysfunction is prospectively associated with global cognitive impairment in later life.

Methods

This cross-cohort study integrates 2 large longitudinal datasets, Whitehall II and the National Survey for Health and Development (NSHD), on data collected in the Whitehall II study between 2002-2004, 2007-2009, and 2012-2013; and for NSHD between 2006-2010 and in 2015. Serial salivary cortisol samples were collected multiple times within a 24-hour period at mean ages 61.2 and 65.9 years in Whitehall II and at age 60-64 years from NSHD participants. Cortisol profile is defined using cortisol awakening response and am:pm ratio. Cognitive function was measured using the Mini-Mental State Examination in Whiteha

SUBMITTER: Tsui A 

PROVIDER: S-EPMC6988984 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature