Short-Chain Fatty Acids Improve Poststroke Recovery via Immunological Mechanisms.

ABSTRACT: Recovery after stroke is a multicellular process encompassing neurons, resident immune cells, and brain-invading cells. Stroke alters the gut microbiome, which in turn has considerable impact on stroke outcome. However, the mechanisms underlying gut-brain interaction and implications for long-term recovery are largely elusive. Here, we tested the hypothesis that short-chain fatty acids (SCFAs), key bioactive microbial metabolites, are the missing link along the gut-brain axis and might be able to modulate recovery after experimental stroke. SCFA supplementation in the drinking water of male mice significantly improved recovery of affected limb motor function. Using in vivo wide-field calcium imaging, we observed that SCFAs induced altered contralesional cortex connectivity. This was

SUBMITTER: Sadler R 

PROVIDER: S-EPMC6989004 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature