Ontology highlight
ABSTRACT:
SUBMITTER: Dubey R
PROVIDER: S-EPMC6989039 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Nature chemical biology 20200113 2
Genetic screens in cultured human cells represent a powerful unbiased strategy to identify cellular pathways that determine drug efficacy, providing critical information for clinical development. We used insertional mutagenesis-based screens in haploid cells to identify genes required for the sensitivity to lasonolide A (LasA), a macrolide derived from a marine sponge that kills certain types of cancer cells at low nanomolar concentrations. Our screens converged on a single gene, LDAH, encoding ...[more]