The impact of donor and recipient common clinical and genetic variation on estimated glomerular filtration rate in a European renal transplant population.

ABSTRACT: Genetic variation across the human leukocyte antigen loci is known to influence renal-transplant outcome. However, the impact of genetic variation beyond the human leukocyte antigen loci is less clear. We tested the association of common genetic variation and clinical characteristics, from both the donor and recipient, with posttransplant eGFR at different time-points, out to 5 years posttransplantation. We conducted GWAS meta-analyses across 10 844 donors and recipients from five European ancestry cohorts. We also analyzed the impact of polygenic risk scores (PRS), calculated using genetic variants associated with nontransplant eGFR, on posttransplant eGFR. PRS calculated using the recipient genotype alone, as well as combined donor and recipient genotypes were significantly associated wi

SUBMITTER: Stapleton CP 

PROVIDER: S-EPMC6989089 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature