Ontology highlight
ABSTRACT:
SUBMITTER: Stapleton CP
PROVIDER: S-EPMC6989089 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Stapleton Caragh P CP Heinzel Andreas A Guan Weihua W van der Most Peter J PJ van Setten Jessica J Lord Graham M GM Keating Brendan J BJ Israni Ajay K AK de Borst Martin H MH Bakker Stephan J L SJL Snieder Harold H Weale Michael E ME Delaney Florence F Hernandez-Fuentes Maria P MP Reindl-Schwaighofer Roman R Oberbauer Rainer R Jacobson Pamala A PA Mark Patrick B PB Chapman Fiona A FA Phelan Paul J PJ Kennedy Claire C Sexton Donal D Murray Susan S Jardine Alan A Traynor Jamie P JP McKnight Amy Jayne AJ Maxwell Alexander P AP Smyth Laura J LJ Oetting William S WS Matas Arthur J AJ Mannon Roslyn B RB Schladt David P DP Iklé David N DN Cavalleri Gianpiero L GL Conlon Peter J PJ
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20190328 8
Genetic variation across the human leukocyte antigen loci is known to influence renal-transplant outcome. However, the impact of genetic variation beyond the human leukocyte antigen loci is less clear. We tested the association of common genetic variation and clinical characteristics, from both the donor and recipient, with posttransplant eGFR at different time-points, out to 5 years posttransplantation. We conducted GWAS meta-analyses across 10 844 donors and recipients from five European ances ...[more]