Microbes as Master Immunomodulators: Immunopathology, Cancer and Personalized Immunotherapies.

ABSTRACT: The intricate interplay between the immune system and microbes is an essential part of the physiological homeostasis in health and disease. Immunological recognition of commensal microbes, such as bacterial species resident in the gut or lung as well as dormant viral species, i.e., cytomegalovirus (CMV) or Epstein-Barr virus (EBV), in combination with a balanced immune regulation, is central to achieve immune-protection. Emerging evidence suggests that immune responses primed to guard against commensal microbes may cause unexpected pathological outcomes, e.g., chronic inflammation and/or malignant transformation. Furthermore, translocation of immune cells from one anatomical compartment to another, i.e., the gut-lung axis via the lymphatics or blood has been identified as an important fact

SUBMITTER: Lerias JR 

PROVIDER: S-EPMC6989410 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature