The histomolecular criteria established for adult anaplastic pilocytic astrocytoma are not applicable to the pediatric population.

ABSTRACT: Pilocytic astrocytoma (PA) is the most common pediatric glioma, arising from a single driver MAPK pathway alteration. Classified as a grade I tumor according to the 2016 WHO classification, prognosis is excellent with a 10-year survival rate > 95% after surgery. However, rare cases present with anaplastic features, including an unexpected high mitotic/proliferative index, thus posing a diagnostic and therapeutic challenge. Based on small histomolecular series and case reports, such tumors arising at the time of diagnosis or recurrence have been designated by many names including pilocytic astrocytoma with anaplastic features (PAAF). Recent DNA methylation-profiling studies performed mainly on adult cases have revealed that PAAF exhibit a specific methylation signature, thus constituting a

SUBMITTER: Gareton A 

PROVIDER: S-EPMC6989446 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature