Genome-Wide Association Study of Brain Connectivity Changes for Alzheimer's Disease.

ABSTRACT: Variations in the human genome have been found to be an essential factor that affects susceptibility to Alzheimer's disease. Genome-wide association studies (GWAS) have identified genetic loci that significantly contribute to the risk of Alzheimers. The availability of genetic data, coupled with brain imaging technologies have opened the door for further discoveries, by using data integration methodologies and new study designs. Although methods have been proposed for integrating image characteristics and genetic information for studying Alzheimers, the measurement of disease is often taken at a single time point, therefore, not allowing the disease progression to be taken into consideration. In longitudinal settings, we analyzed neuroimaging and single nucleotide polymorphism datasets obt

SUBMITTER: Elsheikh SSM 

PROVIDER: S-EPMC6989662 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature