Chloroquine differentially modulates coronary vasodilation in control and diabetic mice.

ABSTRACT:

Background and purpose

Chloroquine is a traditional medicine to treat malaria. There is increasing evidence that chloroquine not only induces phagocytosis but regulates vascular tone. Few reports investigating the effect of chloroquine on vascular responsiveness of coronary arteries have been made. In this study, we examined how chloroquine affected endothelium-dependent relaxation in coronary arteries under normal and diabetic conditions.

Experimental approach

We isolated coronary arteries from mice and examined endothelium-dependent relaxation (EDR). Human coronary endothelial cells and mouse coronary endothelial cells isolated from control and diabetic mouse (TALLYHO/Jng [TH] mice, a spontaneous type 2 diabetic mouse model) were used for the molecular biological or cytoso

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC6989957 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature