Pharmacological targeting of β₂ -adrenoceptors is neuroprotective in the LPS inflammatory rat model of Parkinson's disease.

ABSTRACT:

Background and purpose

Chronic inflammation may play a role in the pathogenesis of Parkinson's disease (PD). Noradrenaline is an endogenous neurotransmitter with anti-inflammatory properties. In the present investigation, we assessed the immunomodulatory and neuroprotective efficacy of pharmacologically targeting the CNS noradrenergic system in a rat model of PD.

Experimental approach

The impact of treatment with the β₂ -adrenoceptor agonists clenbuterol and formoterol was assessed in the intranigral LPS rat model of PD. The immunomodulatory potential of formoterol to influence the CNS response to systemic inflammation was also assessed.

Key results

LPS-induced deficits in motor function (akinesia and forelimb-use asymmetry) and nigrostriatal dopamine loss

SUBMITTER: O'Neill E 

PROVIDER: S-EPMC6989960 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature