Genetic changes in rat proximal nerve stumps after sciatic nerve transection.

ABSTRACT:

Background

Peripheral nerves can self-regenerate after traumatic injury, although their self-regeneration ability is limited after severe nerve injury. After peripheral nerve injury, the distal nerve stumps undergo Wallerian degeneration while the proximal nerve stumps undergo a regeneration process.

Methods

Here, to decipher genetic changes and involved biological processes in the proximal nerve stumps after peripheral nerve injury, microarray data (GSE30165) were analyzed. Differentially expressed genes in the proximal nerve stumps at 0.5 h, 1 h, 3 h, 6 h, 9 h, 1 d, 4 d, 7 d, and 14 d after rat sciatic nerve transection were subjected to Ingenuity pathway analysis (IPA) bioinformatic analysis.

Results

Cytokine signaling, cellular immune response, nuclear receptor si

SUBMITTER: Gong L 

PROVIDER: S-EPMC6990034 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature