Factors Promoting Conduction Slowing as Substrates for Block and Reentry in Infarcted Hearts.

ABSTRACT: The development of effective and safe therapies for scar-related ventricular tachycardias requires a detailed understanding of the mechanisms underlying the conduction block that initiates electrical re-entries associated with these arrhythmias. Conduction block has been often associated with electrophysiological changes that prolong action potential duration (APD) within the border zone (BZ) of chronically infarcted hearts. However, experimental evidence suggests that remodeling processes promoting conduction slowing as opposed to APD prolongation mark the chronic phase. In this context, the substrate for the initial block at the mouth of an isthmus/diastolic channel leading to ventricular tachycardia is unclear. The goal of this study was to determine whether electrophysiological paramet

SUBMITTER: Campos FO 

PROVIDER: S-EPMC6990374 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature