A Spatiotemporal Ventricular Myocyte Model Incorporating Mitochondrial Calcium Cycling.

ABSTRACT: Intracellular calcium (Ca²⁺) cycling dynamics in cardiac myocytes are spatiotemporally generated by stochastic events arising from a spatially distributed network of coupled Ca²⁺ release units that interact with an intertwined mitochondrial network. In this study, we developed a spatiotemporal ventricular myocyte model that integrates mitochondria-related Ca²⁺ cycling components into our previously developed ventricular myocyte model consisting of a three-dimensional Ca²⁺ release unit network. Mathematical formulations of mitochondrial membrane potential, mitochondrial Ca²⁺ cycling, mitochondrial permeability transition pore stochastic opening and closing, intracellular reactive oxygen species signaling, and oxidized Ca²⁺/ca

SUBMITTER: Song Z 

PROVIDER: S-EPMC6990377 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature